Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
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منابع مشابه
Streptozotocin-Induced Diabetes Models: Pathophysiological Mechanisms and Fetal Outcomes
Glucose homeostasis is controlled by endocrine pancreatic cells, and any pancreatic disturbance can result in diabetes. Because 8% to 12% of diabetic pregnant women present with malformed fetuses, there is great interest in understanding the etiology, pathophysiological mechanisms, and treatment of gestational diabetes. Hyperglycemia enhances the production of reactive oxygen species, leading t...
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The cellular and molecular requirements for beta-cell damages in an immune-mediated toxin-induced insulin-dependent diabetes mellitus have been studied in the model of multiple low-dose streptozotocin-induced diabetes in rats and mice. It was found that strain-related susceptibility to diabetes induction correlated with a higher level of IL-2, IFN-gamma, and TNF-alpha production, whereas such d...
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Background and objectives: Melissa officinalis (MO) has shown antioxidant and anti-inflammatory properties and is traditionally believed to have anti-hyperglycemic effects. This study aims to evaluate the protective effects of MO on streptozotocin (STZ) induced pancreatic damage and thereupon diabetes in rats. Methods: STZ (60 mg/kg) was injected intraperitoneally to the rats in order to induc...
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Diabetes mellitus (DM) is mainly characterized by hyperglycemia [1] with an imbalance of carbohydrate, protein and fat metabolism due to reduced production of insulin from pancreas (defects in insulin secretion), or when insulin cannot be used efficiently by the body (defect in insulin action), or both [1,2]. Two major forms of diabetes are Type I DM (TIDM) and Type II DM (TIIDM). TIDM is also ...
متن کاملMechanisms Underlying Sesamolin-Induced Attenuation of Vascular Dysfunction in Rats With Streptozotocin-Induced Diabetes
Article history: Received: 20 Nov 2010 Revised: 27 Jan 2011 Accepted: 09 Feb 2011
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ژورنال
عنوان ژورنال: BioMed Research International
سال: 2014
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2014/819065